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GHS 202A
This course approaches the global burden of communicable disease from the perspectives of biology, history, epidemiology, economics, prevention and control. GHS202A will broadly cover the basic principles of infection and immunity, the pathogenesis and major types of communicable infections, with a focus on HIV, malaria and tuberculosis, and the public health control measures for major communicable diseases. Through a combination of lectures, seminars and independent study, students will learn about major communicable diseases, concepts of surveillance and outbreak investigations, vaccine control programs, low-technology solutions to disease control in the developing world and the global/economic politics of infectious diseases.
Lectures, seminars, independent study, assigned papers
3 units credit over one quarter
- 1.5 hours of lecture per week
- 1.5 hours of seminar plus three hours of independent study per week
At the end of the course, students should be able to:
- Know the major communicable diseases of global importance, including HIV, malaria, and tuberculosis
- Enumerate the major neglected diseases of global health importance and their control, including disease burden, clinical features, distribution and control
- Describe the main principals of prevention and control of communicable diseases including surveillance, appropriate use of therapies, vaccines, vector control, behavioral modification
- Understand barriers to effectively controlling communicable diseases in resource-poor settings, including poverty, limited technology and infrastructure, and socio-political constraints
- Explain the principals of infection, immunity, microbial ecology and pathogenesis
- Cite examples of effective communicable disease interventions including vector control, vaccination, quarantine, and public health measures
- Describe the major historical milestones of the HIV epidemic and the essential obstacles to infection control
- Enumerate examples of emerging infections and describe the mechanisms by which they arise and spread
- Introduction to course requirements and syllabus. Description of writing assignment/ How to write a mock NIH-grant proposal (Phil Rosenthal)
- Lecture on HIV part I (History, epidemiology and prevention) (Monica Gandhi). Seminar in international HIV epidemiology
- Lecture on HIV in Africa history (Jay Levy)
- Lecture on HIV part II (Monica Gandhi). Biology, life cycle, host-viral interactions, disease manifestations, opportunistic infections, antiretroviral treatments and access. Seminar on ethics of research in international setting (Steve Morin)
- Lecture on malaria (Phil Rosenthal). Epidemiology, biology, host-parasite interactions, clinical features, diagnosis, treatment, prevention (bed nets, vector control, chemoprophylaxis, vaccines). Student presentation#1
- Lecture on UCSF malaria research in Africa (Phil Rosenthal/Grant Dorsey) Seminar on malaria (G. Dorsey)
- Special lecture: Shrinking the Malaria Map: 1900 to 2025 (Sir Richard Feachem)
- Lecture on tuberculosis (P. Hopewell). Basic concepts, history, host-bacterial interactions, routes of spread, epidemiology, global inequities, prevention and control strategies. Student presentation #2
- Seminar on TB-HIV (Edwin Charlebois)
- Lecture: "Pa'bajo con el dengue!": Partnerships for research and control of infectious diseases in Latin America (Eve Harris).
- Lecture on helminths and protozoa of medical importance (Phil. Rosenthal). Student
presentation #3. Lunch with students, Phil, Monica
- Lecture on Global Health and the Eye (Tom Lietman). Student presentation #4
- Lecture on Pneumonia, Meningitis (Art Reingold).
- Seminar: Outbreak investigation (Art Reingold). Student presentation #5
- Lecture on vaccine preventable diseases and disease
control strategies (George. Rutherford). Student presentation #6. Seminar on vaccines
- Lecture on influenza, SARS and avian flu (J. Louie). Student presentation #7
- Special presentation: Nathan Wolfe. Surveillance of emerging diseases
- Short presentations by all students on their mock NIH grant proposal (maximum 15 minutes each). Course wrap-up and lunch in Chinatown
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